University Staff

Dr. Karen K.L. CHAN hong kong university logo queen mary hosipital logo

Dr. Karen K.L. CHAN (陳嘉倫醫生)

Clinical Associate Professor
MBBChir (UK); FRCOG; FHKCOG; FHKAM (O&G); Cert RCOG (Gynaecological; Oncology)
  • location
    Professorial Block, Queen Mary Hospital
  • telephone
    (852)-2255-4518
  • facsimile
    (852)-2855-0947
  • kklchan@hku.hk
  • HKU Scholars Hub
Research Interests

General Gynaecology

Gynaecological Oncology

Publications

2017
  • Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, Chan KK, Ngan HY, Chan DW. MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis. Mol Cancer. 2017 Jan 17;16(1):11. doi: 10.1186/s12943-017-0582-2.

  • SF Ngu, N Wei, TTC Kwan, MMY Chu, KY Tse, KKL Chan, HYS Ngan. Impact of different educational interventions on psychosocial wellbeing of Hong Kong Chinese women with a positive high-risk human papillomavirus and normal cervical cytology. Journal of Psychosomatic Obstetrics & Gynecology 2017: 10: 1 – 10.

2016
  • Chu MM, Tse KY, Chan KK, Cheung AN, Ngan HY. Placental site trophoblastic tumour – a distinct entity of gestational trophoblastic disease: experience from a tertiary referral center in Hong Kong. J Reprod Med. 2016 Aug;61(4):351-6

2015
  • KY Tse, KKL Chan, KF Tam, HYS Ngan. Current management of gestational trophoblastic disease. Obstetrics, Gynaecology & Reproductive Medicine 2015; 25 (1): 12 – 21

  • EY Lee, ES Hui, KK Chan, KY Tse, WK Kwong, TY Chang, Q Chan, PL Khong. The relationship between intravoxel incoherent motion diffusion-weighted MRI and dynamic contrast-enhanced MRI in tissue perfusion of cervical cancers. J Magn Reson Imaging.  2015; 42: 454 - 9

  • Siu KY, Kong DS, Ngai SY, Chan HY, Jiang L, Wong ESY, Liu S, Chan KKL, Ngan HYS and Cheung ANY. p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation. PLoS One 2015, 10(7): e0133467.

  • Mak VC, Wong OG, Siu MK, Wong ES, Ng WY, Wong RW, Chan KK, Ngan HY, Cheung AN. FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling. Am J Pathol 2015 Jul;185(7):2038-48.

  • Chu MM, Ma Y, Tse KY, Chan KK, Ngan HY. Cyclophosphamide, hydroxyurea, actinomycin D, methotrexate, and vincristine in the treatment of gestational trophoblastic neoplasia. International Journal of Gynecological Cancer 2015 Mar;25(3):498-503.

2014
  • KY Tse, PPC Ip, KKL Chan. Human papillomavirus and cervical cancer. J Paed Obs Gyn 2014; Sep / Oct: 213 – 20

  • Chan KKL, Leung THY, Chan DW, Wei N, Lau TY, Liu S, Siu KY and Ngan HYS. Targeting estrogen receptor subtypes (ERalpha and ERbeta) with selective ER modulators in ovarian cancer. Journal of Endocrinology 2014, 221: 325-336.

  • Cai C, Shi L, Liu VWS, Tang WM, Liu J, Leung THY, Chan KKL, Yam JWP, Yao KM, Ngan HYS and Chan DW. Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling. Oncotarget 2014, 5: 7549-62.

2013
  • Lee EY, Khong PL, Tse KY, Chan KK, Chu MM, Ngan HY. Differentiation of aggressive and indolent subtypes of uterine sarcoma using maximum standardized uptake value. Nucl Med Commun. 2013; 34(12):1185-9.

  • Chan KK, Chen CA, Nam JH, Ochiai K, Wilailak S, Choon AT, Sabaratnam S, Hebbar S, Sicken J, Schodin BA and Sumpaico WW. The use of HE4 in the prediction of ovarian cancer in Asian womenn with a pelvic mass. Gynecolgic Oncology 2013, 128 (2), 239-44. [PubMed]

  • Leung TH, Wong SC, Chan KK, Chan DW, Cheung AN, Ngan HY.The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells. Br J Cancer. 2013 Aug 20;109(4):965-75. [PubMed]

2012
  • KY Tse, KKL Chan, KF Tam, HY Ngan. Update on gestastional trophoblastic disease. Obstetrics, Gynaecology & Reproductive Medicine 2012; 22: 7 – 15

  • Chan DW, Hui WY, Cai C, Liu X, Yung MH, Mak SL, Leung THY, Chan KKL, Ngan HYS. Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells. PLoS ONE. 2012, 7: e52578. [PubMed]

  • Chan DW, Mak CS, Leung TH, Chan KK, Ngan HY. Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer. Oncotarget. 2012 Dec;3(12):1546-56. [PubMed]

  • Chan KKL, Kwan TTC, Yao T, Tam KF, Cheung ANY, Ngan HYS. Human papillomavirus vaccine: What are women most concerned about? J Obstet Gynaecol Res. 2012, 38(1): 23-30. 

  • Cheung ANY, Chan KKL. Perplexing hCG profile after evacuation of hydatidiform mole. Lancet. 2012;379:98-100

  • Kwan TT, Lo SS, Tam KF, Chan KK, Ngan HY. Assessment of knowledge and stigmatizing attitudes related to human papillomavirus among Hong Kong Chinese healthcare providers. Int J Gynaecol Obstet. 2012 Jan;116(1):52-6. 

  • Shek WM, Lao TT, Chan KL. Mode of anaesthesia on fetal acid-base status at caesarean section. Journal of Perinatal Medicine 2012; 40(6): 653-7.

  • Wei N, Liu SS, Chan KK, Ngan HY. Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer. PLoS One. 2012;7(1):e30311. [PubMed]

2011
  • Chan KK, Yao TJ, Jones B, Zhao JF, Ma FK, Leung CY, Lau SK, Yip MW, Ngan HY. The use of Chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer: a double-blind placebo-controlled randomized trial with immunological monitoring. Ann Oncol. 2011 Oct;22(10):2241-9. [PubMed]

  • Chan DW, Liu VW, Leung LY, Yao KM, Chan KK, Cheung AN, Ngan HY. Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells. J Pathol. 2011 Dec;225(4):525-34. [PubMed]

  • Chan KL, Brownridge DA, Tiwari A, Fong DY, Leung WC, Ho PC. Associating pregnancy with partner violence against Chinese women. J Interpers Violence. 2011 May;26(7):1478-500.

  • Kwan TT, Cheung AN, Lo SS, Lee PW, Tam KF, Chan KK, Ngan HY. Psychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: a prospective study. Acta Obstet Gynecol Scand. 2011 May;90(5):445-51. 

  • Liu SS, Chan KY, Leung RC, Chan KK, Tam KF, Luk MH, Lo SS, Fong DY, Cheung AN, Lin ZQ, Ngan HY. Prevalence and risk factors of Human Papillomavirus (HPV) infection in southern Chinese women - a population-based study. PLoS One. 2011 May 3;6(5):e19244.

  • Ngan HY, Garland SM, Bhatla N, Pagliusi SR, Chan KK, Cheung AN, Chu TY, Domingo EJ, Qiao YL, Park JS, Tay EH, Supakarapongkul W. Asia oceania guidelines for the implementation of programs for cervical cancer prevention and control. J Cancer Epidemiol. 2011;2011:794861. 

2010
  • Hu YJ, Ip PP, Chan KK, Tam KF, Ngan HY. Ovarian clear cell carcinoma with choriocarcinomatous differentiation: report of a rare and aggressive tumor. Int J Gynecol Pathol 2010;29:539-45.

  • Janda M, Gebski V, Brand A, Hogg R, Jobling TW, Land R, Manolitsas T, McCartney A, Nascimento M, Neesham D, Nicklin JL, Oehler MK, Otton G, Perrin L, Salfinger S, Hammond I, Leung Y, Walsh T, Sykes P, Ngan HYS, Garrett A, Laney M, Ng TY, Tam KF, Chan KKL, Wrede CDH, Pather S, Simcock B, Farrell R, Obermair A. Quality of life after total laparoscopic hysterectomy versus total abdominal hysterectomy for stage I endometrial cancer (LACE): a randomized trial. Lancet Oncol. 2010;11:772-80. (Publication No. : 175333) 

  • Kwan TT, Tam KF, Lee PW, Lo SS, Chan KK, Ngan HY. De-stigmatising human papillomavirus in the context of cervical cancer: a randomised controlled trial. Psychooncology 2010;19:1329-39.

  • Ngan HYS, Cheung ANY, Tam KF, Chan KKL, Tang HW, Bi D, Descamps D, Bock HL. Human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy Chinese women from Hong Kong, Hong Kong Med J 2010;16:171-9. (Publication No. : 170837) 

2009
  • KY Tse, KKL Chan, KF Tam, Ngan HY. Gestational trophoblastic disease. Obstetrics, Gynaecology & Reproductive Medicine 2009; 19: 89 – 97

2008
  • KK Chan, KF Tam, KY Tse, Ngan HY. The role of regular physical examination in the detection of ovarian cancer recurrence. Gynecol Oncol 2008; 110; 158 – 61

  • Chan KK, Wei N, Liu SS, Xiao-Yun L, Cheung AN, Ngan HY. Estrogen receptor subtypes in ovarian cancer: a clinical correlation. Obstet Gynecol. 2008 Jan;111(1):144-51. [PubMed]

  • Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa T, Chan KK, Ngan HY. Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis. 2008 Sep;29(9):1742-50.  [PubMed]

Research Grants
  • Differential roles of estrogen receptor subtypes and variants in ovarian cancer: implications for personalized hormonal treatment. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2013-2014 (Principal Investigator) HK$ 736,128 (2013-2016)