University Staff

Dr. Calvin K.F. LEE hong kong university logo queen mary hosipital logo

Dr. Calvin K.F. LEE (李啟輝博士)

Associate Professor
BSc (HKBU); PhD (CUHK)
  • location
    L7-49, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, Pokfulam, Hong Kong
  • telephone
    (852)-3917-9369
  • facsimile
    (852)-2816-1947
  • ckflee@hku.hk
  • HKU Scholars Hub
Research Interests

1.  Molecular Regulation on Human Endometrial Receptivity: Effect of steroid hormones, Endocrine Disrupting Chemicals (EDCs) and secretory molecules (Open for MPhil/PhD study)  

  • GRF Funded Project: Human embryonic stem cell-derived trophoblastic cells for the development of a novel implantation model. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2014-2015 (Principal Investigator) HK$1,198,800 (2014-2016)
  • GRF Funded Project: Bisphenol A analogues: Mechanistic actions on Embryo implantation and Endometrial Receptivity. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2015-2016 (Principal Investigator) HK$920,395 (2015-2017)

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2.  Interaction of the Embryos and the Female Reproductive Tract: Roles of  Olfm1 and miRNAs. (Open for MPhil/PhD study)

  • GRF Funded Project: Embryo-Female Reproductive Tract Interaction: A study on the role of embryo-derived factor(s) on endometrial receptivity through microRNA regulation. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2013-2014 (Principal Investigator) HK$ 649,524(2013-2015)

3.  Transgenic approach to study Spermatogenesis and stem cell properties.

 Paper Highlight

                                          1. Kodithuwakku SP, Pang RT, Ng EH, Cheung AN, Horne AW, Ho PC, Yeung WS, Lee KF. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92(2):256-64. (We are the first to report the differential expression of olfactomedin-1 in tubal ectopic pregnancy and we further proposed a functional role of olfactomedin-1 on embryo attachment using an in vitro spheroid-Fallopian tubal cells coculture model)
                                          2. Kodithuwakku SP, Ng PY, Liu Y, Ng EHY, Yeung WSB, Ho PC, Lee KF. Hormonal regulation of endometrial olfactomedin expression and its suppressive effect on spheroid attachment onto endometrial epithelial cells. Hum Reprod 2011;26:167-175. (We are the first to report the differential expression of endometrial olfactomedin-1 protein in patient receiving IVF treatment and further proposed a suppressive effect of olfactomedin-1 on embryo attachment using an in vitro spheroid-endometrial cells coculture model)
                                          3. Pang RTK, Leung ON, Ye T, Liu W, Chiu CN, Lam KW, Lee KF, Yeung WSB. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 2010;31:1037-1044. (The role of miR-34a in cervical tumorigenesis is not fully known, however, it is predicted that Notch1 and Jagged1 were targets of miR-34a. We demonstrated that miR-34a suppresses the invasiveness of HeLa and JAr cells through regulation of the Notch pathway and its downstream matrix degrading enzyme. The paper was cited >70 times.)
                                          4. Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. (We are the first using microarray to compare the endometrial gene expression patterns in patient receiving hormonal stimulation and identified a number of hormone-regulated gene and pathway import for implantation process. The paper was cited >40 times, and was selected as cover photo of the Journal.)
 
PubMed Search

Author Name: Lee Kai-Fai

Publications

2018
  • Ahmad SF, Brown JK, Campbell LL, Koscielniak M, Oliver C, Wheelhouse N, Entrican G, McFee S, Wills GS, McClure MO, Horner PJ, Gaikoumelou S, Lee KF, Critchley HOD, Duncan WC, Horne AW. Pelvic Chlamydial infection predisposes to ectopic pregnancy by upregulating integrin b1 to promote embryo-tubal attachment. EBioMedicine. 2018 Mar;29:159-165. doi: 10.1016/j.ebiom.2018.02.020. Epub 2018 Feb 23.

  • Wang X, Wang GC, Rong J, Wang SW, Ng TB, Zhang YB, Lee KF, Zheng L, Wong HK, Yung KKL, Sze SCW. Identification of Steroidogenic Components Derived from Gardenia jasminoides Fllis potentially useful for treating Postmenopausal Syndrome. Front Pharmacol. 2018 May 30;9:390. doi: 10.3389/fphar.2018.00390. eCollection 2018.

2017
  • Li HWR, Li YX, Li TT, Fan H, Ng EH, Yeung WS, Ho PC, Lee KF. Effect of ulipristal acetate and mifepristone at emergency contraception dose on the embryo-endometrial attachment using an in vitro human trophoblastic spheroid and endometrial cell co-culture model. Hum Reprod. 2017 Dec 1;32(12):2414-2422. doi: 10.1093/humrep/dex328.

  • Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, Chan KK, Ngan HY, Chan DW. MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis. Mol Cancer. 2017 Jan 17;16(1):11. doi: 10.1186/s12943-017-0582-2.

  • Wang SW, Cheung HP, Tong Y, Lu J, Ng TB, Zhang YB, Zhang ZJ, Lee KF, Lam JK, Sze SC. Steroidogenic effect of Erxian decoction for relieving menopause via the p-AKt/PKB pathway in vitro and in vivo. J Ethnopharmacol. 2017 Jan 4;195:188-195. doi: 10.1016/j.jep.2016.11.018. Epub 2016 Nov 18.

2016
  • Lu J, Wong RN, Zhang L, Wong RY, Ng TB, Lee KF, Zhang YB, Lao LX, Liu JY, Sze SC. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different dioscorea species in vitro using both phenotypic and target-based approaches: Implication for treating Menopause. Appl Biochem Biotechnol. 2016 Sep;180(1):79-93. doi: 10.1007/s12010-016-2084-x. Epub 2016 Apr 30.

  • Liu JY, Chen XX, Tang SC, Sze SC, Feng YB, Lee KF, Zhang KY. Chinese medicines in the treatment of  experimental diabetic nephropathy. Chin Med. 2016 Feb 24;11:6. doi: 10.1186/s13020-016-0075-z. eCollection 2016.

2015
  • Liu J, Chen X, Tang SCW, Lao L, Sze CWS, Lee CKF and Zhang Y. Edible plants from traditional Chinese medicine is a promising alternative for the management of diabetic nephropathy. Journal of Functional Foods 2015, 14(2015): 12-22.

  • Wang B, Ye TM, Lee KF, Chiu PC, Pang RT, Ng EH, Yeung WS.Annexin A2 Acts as an Adhesion Molecule on the Endometrial Epithelium during Implantation in Mice. PLoS One. 2015 Oct 7;10(10):e0139506. [Medline]

  • Kottawatta KS, So KH, Kodithuwakku SP, Ng EH, Yeung WS, Lee CKF. MicroRNA-212 Regulates the Expression of Olfactomedin 1 and C-Terminal Binding Protein 1 in Human Endometrial Epithelial Cells to Enhance Spheroid Attachment In Vitro. Biol Reprod 2015 Nov;93(5):109.

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  • Lee YL, Fong SW, Chen AC, Li T, Yue C, Lee CL, Ng EH, Yeung WS, Lee KF.Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod. 2015 Sep 7. pii: dev223. [Epub ahead of print]

  • Lee CL, Guo Y, So KH, Vijayan M, Wong HHV, Yao Y, Lee CKF, Chiu CN and Yeung WSB. Soluble human leukocyte antigen G5 polarizes differentiation of macrophages towards a decidual macrophage-like phenotype. Human Reproduction 2015, 30: 2263-74.

  • Wong KL, Lai YM, Li KW, Lee KF, Ng TB, Cheung HP, Zhang Y, Lao L, Wong RNS, Shaw PC, Wong JH, Zhang Z, Lam JKW, Ye W, Sze CWS. A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Scientific Reports 2015, 5: 10179. doi.org/10.1038/srep10179. [Medline]

  • So KH, Kodithuwakku SP, Kottawatta KS, Li RH, Chiu PC, Cheung AN, Ng EH, Yeung WS, Lee KF.Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1. Fertil Steril. 2015 May 18. pii: S0015-0282(15)00304-0. doi: 10.1016/j.fertnstert.2015.04.030. [Epub ahead of print]

2014
  • Liu J, Petersen NJ, Lee KF, Hansen SH, Lao L, Sze C, Zhang Y. Application of temperature-correlated mobility theory for optimizing the MEKC separation of the main lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction. Electrophoresis. 2014 Oct;35(20):2907-14. doi: 10.1002/elps.201400007. Epub 2014 Aug 19. [PubMed]

  • Horne AW, Brown JK, Nio-Kobayashi J, Abidin HB, Adin ZE, Boswell L, Burgess S, Lee KF, Duncan WC. The Association between Smoking and Ectopic Pregnancy: Why Nicotine Is BAD for Your Fallopian Tube. PLoS One. 2014 Feb 20;9(2):e89400. [PubMed]

  • Cheong AW, Pang RT, Liu WM, Kottawatta KS, Lee KF, Yeung WS. MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos. Hum Reprod. 2014 Jan 12. [Epub ahead of print] [PubMed]

2013
  • Tsang H, Cheung TY, Kodithuwakkua SP, Chai J, Yeung WS, Wong CKC, Lee KF. Perfluorooctanoate Suppresses Spheroid Attachment on Endometrial Epithelial Cells Through Peroxisome Proliferator-Activated Receptor Alpha and Down-Regulation of Wnt Signaling. Reprod Toxicol. 2013 Dec;42:164-71. doi: 10.1016/j.reprotox.2013.08.001. Epub 2013 Aug 24. [Medline]

  • Lee VC, Gao J, Lee KF, Ng EH, Yeung WS, Ho PC. The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta. Hum Reprod 2013 Nov;28(11):2912-9.[PubMed]

  • Guo YF, Lee CL, So KH, Gao J, Yeung WSB, Yao YQ, Lee KF. Soluble Human Leukocyte Antigen-G5 Activates Extracellular Signal-Regulated Protein Kinase Signaling and Stimulates Trophoblast Invasion. PLoS One 2013 Oct 1;8(10):e76023. [PubMed]

  • Liu JY, Lee KF, Sze CW, Tong Y, Tang SC, Ng TB, Zhang YB. Intestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control. J Pharm Pharmacol. 2013 May;65(5):621-33. [PubMed]

  • Chan RW, Mak AS, Yeung WS, Lee KF, Cheung AN, Ngan HY, Wong AS. Human female reproductive tract epithelial cell culture. Methods Mol Biol. 2013;945:347-63. [PubMed]

2012
  • Chen AC, Lee YL, Hou DY, Fong SW, Peng Q, Pang RT, Chiu PC, Ho PC, Lee KF, Yeung WS. Study of transforming growth factor alpha for the maintenance of human embryonic stem cells. Cell Tissue Res. 2012 Nov;350(2):289-303. [Medline]

  • Gao J, Zuo Y, So KH, Yeung WSB, Ng EHY, Lee KF. Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment. Spermatogenesis. 2012;2(1):53-62. [Medline]

  • Kodithuwakku SP, Pang RT, Ng EH, Cheung AN, Horne AW, Ho PC, Yeung WS, Lee KF. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92(2):256-64. [Medline]

  • Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A, Yeung WS. Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. PLoS One. 2012;7(9):e45633. [Medline]

  • Liu J, Cai YZ, Wong RN, Lee KF, Tang SC, Sze SC, Tong Y, Zhang Y. Comparative analysis of caffeoylquinic acids and lignans in roots and seeds among various burdock (Arctium lappa) genotypes with high antioxidant activity. J Agric Food Chem. 2012 Apr 25;60(16):4067-75. [Medline]

  • Liu WM, Pang RT, Cheong AW, Ng EH, Lao K, Lee KF, Yeung WS. Involvement of microRNA lethal-7a in the regulation of embryo implantation in mice. PLoS One. 2012;7(5):e37039. [Medline]

  • Liu WM, Pang RT, Chiu PC, Wong BP, Lao K, Lee KF, Yeung WS. Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci USA. 2012;109(2):490-4. [Medline]

  • So KH, Lee CL, Yeung WS, Lee KF. Glycodelin suppresses endometrial cell migration and invasion but stimulates spheroid attachment. Reprod Biomed Online. 2012;24(6):639-45. [PubMed]

  • Song JX, Sze SC, Ng TB, Lee CK, Leung GP, Shaw PC, Tong Y, Zhang YB. Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? J Ethnopharmacol. 2012 Feb 15;139(3):698-711. [PubMed]

  • Tsang H, Cheung TY, Kodithuwakku SP, Chai J, Yeung WS, Wong CK, Lee KF. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses spheroids attachment on endometrial epithelial cells through the down-regulation of the Wnt-signaling pathway. Reprod Toxicol. 2012 Jan;33(1):60-6. [PubMed]

2011
  • Chai J, Lee KF, Ng EH, Yeung WS, Ho PC. Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles. Fertil Steril. 2011 Sep;96(3):764-8. [Medline]

  • Kodithuwakku SP, Ng PY, Liu Y, Ng EHY, Yeung WSB, Ho PC, Lee KF. Hormonal regulation of endometrial olfactomedin expression and its suppressive effect on spheroid attachment onto endometrial epithelial cells. Hum Reprod 2011;26:167-175. [Medline]

  • Lee CL, Chiu PC, Lam KK, Siu SO, Chu IK, Koistinen R, Koistinen H, Seppälä M, Lee KF, Yeung WS. Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy. Hum Reprod. 2011 Mar;26(3):517-26. [Medline]

  • Lee CL, Chiu PC, Pang PC, Chu IK, Lee KF, Koistinen R, Koistinen H, Seppälä M, Morris HR, Tissot B, Panico M, Dell A, Yeung WS. Glycosylation failure extends to glycoproteins in gestational diabetes mellitus: evidence from reduced α2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A. Diabetes. 2011 Mar;60(3):909-17. [Medline]

  • Lin X, Song JX, Shaw PC, Ng TB, Wong RN, Sze SC, Tong Y, Lee KF, Zhang KY. An autoimmunized mouse model recapitulates key features in the pathogenesis of Sjögren's syndrome. Int Immunol. 2011 Oct;23(10):613-24. [Medline]

  • Pang RT, Liu WM, Leung CO, Ye TM, Kwan PC, Lee KF, Yeung WS. miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression. PLoS One. 2011;6:e27878. [Medline]

  • Shaw JL, Wills GS, Lee KF, Horner PJ, McClure MO, Abrahams VM, Wheelhouse N, Jabbour HN, Critchley HO, Entrican G, Horne AW. Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. Am J Pathol. 2011 Jan;178(1):253-60. [Medline]

  • Wan HT, Zhao Y, Wong M, Lee KF, Yeung WS, Giesy JP, Wong CK. Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice. Biol Reprod. 2011 May;84(5):1016-23. [Medline]

  • Wei X, Lee KF, Yeung WSB, Giesy JP, Wong MH, Wong CK. Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice. Reprod Toxicol. 2011 May;31(4):409-17. [Medline]

2010
  • Chiu PC, Wong BS, Lee CL, Lam KK, Chung MK, Lee KF, Koistinen R, Koistinen H, Gupta SK, Seppälä M, Yeung WS. Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx. Hum Reprod 2010;25:2721-33.

  • Duncan WC, McDonald SE, Dickinson RE, Shaw JL, Lourenco PC, Wheelhouse N, Lee KF, Critchley HO, Horne AW. Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Mol Hum Reprod. 2010;16:950-9.

  • Lee CL, Chiu CN, Lam KW, Chan RWS, Chu IK, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Fertil Steril 2010;94:769-71. (Publication No. : 177299) 

  • Lee KF, Lee YL, Chan RWS, Cheong AWY, Ng EHY, Ho PC, Yeung WSB. Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue, Fertility and Sterility. 2010;93:1052-1060. (Publication No. : 175168)

  • Liu Y, Kodithuwakku SP, Ng PY, Chai J, Ng EH, Yeung WS, Ho PC, Lee KF. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. Hum Reprod 2010;25:479-90. [PubMed]

  • Pang RTK, Leung ON, Ye T, Liu W, Chiu CN, Lam KW, Lee KF, Yeung WSB. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells, Carcinogenesis 2010;31:1037-1044. [PubMed]

  • Shaw JL, Oliver E, Lee KF, Entrican G, Jabbour HN, Critchley HO, Horne AW. Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol 2010;177:2509-15.

  • Yeung WSB, Lee YL, Lee KF. Coculture and Assisted Reproduction, In: WL Ledger, SL Tan and AOS Bahathiq, The Fallopian tube in fertility and IVF practice. Cambridge University Press, 2010, 8-17. (Publication No. : 174169)

  • Zhu R., Wong KF, Lee NPY, Lee KF, Luk JMC. HNF1α and CDX2 transcriptional factors bind to cadherin-17 (CDH17) gene promoter and modulate its expression in hepatocellular carcinoma, Journal of Cellular Biochemistry 2010;111:618-626. (Publication No. : 183300) 

  • Zuo Y, Gao J, Yeung WS, Lee KF. The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. Biochem Biophys Res Commun. 2010;401:275-80. 

2009
  • Lam KK, Chiu PC, Chung MK, Lee CL, Lee KF, Koistinen R, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A as a modulator of trophoblast invasion. Hum Reprod. 2009 Sep;24(9):2093-103. [PubMed]

2008
  • Lee YL, Liu Y, Ng PY, Lee KF, Au CL, Ng EH, Ho PC, Yeung WS. Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation. Hum Reprod. 2008 Apr;23(4):894-903. [PubMed]

  • Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WS. Native human zona pellucida glycoproteins: purification and binding properties. Hum Reprod. 2008 Jun;23(6):1385-93. [PubMed]

  • Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020. Epub 2008 Jan 14. [PubMed]

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Current Research Grants
      • Bisphenol A analogues: Mechanistic actions on Embryo implantation and Endometrial Receptivity. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2015-2016 (Principal Investigator) HK$920,395 (2015-2018)
      • Polyamine/Let-7 signaling in embryo implantation and diapause. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2015-2016 (Co-Investigator) HK$1,012,304 (2016-2018)
      • Myometrial cells modulate the activities of endometrial mesenchymal-like stem cells. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2015-2016 (Co-Investigator) HK$889,107 (2016-2018)
      • Human embryonic stem cell-derived trophoblastic cells for the development of a novel implantation model. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2014-2015 (Principal Investigator) HK$1,198,800 (2014-2016)
      • Role of adrenomedullin and inflammatory mediators in pathogenesis of tubal ectopic pregnancy. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2014-2015 (Co-Investigator) HK$ 645,264 (2014-2016)
      • Embryo-Female Reproductive Tract Interaction: A study on the role of embryo-derived factor(s) on endometrial receptivity through microRNA regulation. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2013-2014 (Principal Investigator) HK$ 649,524 (2013-2015)
      • Role of Sirt1 in generation of mouse induced pluripotent stem cells. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2011-2012 (Co-Investigator) HK$ 1,050,000 (2011-2014)
      • Role of microRNA let-7 in implantation of mouse blastocysts. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2010-2011 (Co-Investigator) HK$ 1,032,012 (2010-2013)
      •  
Professional activities
        • 2013-present  President, Hong Kong Society of Reproductive Medicine, HK
        • 2012-present  Honorary Secretary, Hong Kong Society of endocrinology, metabolism and reproduction
        • 2006-2012  Honorary Secretary, Hong Kong Society of Reproductive Medicine, HK
        • 2006-2012  Council Member, Hong Kong Society of endocrinology, metabolism and reproduction
        • 2004-present  Member, Hong Kong Society of endocrinology, metabolism and reproduction, HK
        • 1994-present  Member, American Association on the Advanced of Science (AAAS) member, USA
 

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