University Staff

Dr. Keith C.L. LEE hong kong university logo queen mary hosipital logo

Dr. Keith C.L. LEE (李卓倫博士)

Post-doctoral Fellow
PhD (HK)
  • location
    Rm 747, Laboratory Block, LKS faculty of Medicine, The University of Hong Kong
  • telephone
    (852)-3917-9388
  • facsimile
    (852)-2816-1947
  • kcllee@hku.hk
Research Interests
  • Reproductive Immunology
  • Placental Development
  • Glycobiology

Publications

2015
  • Kim JW, Mahner S, Wu LY, Shoji T, Kim BG, Zhu JQ, Takano T, Park SY, Kong BH, Wu Q, Wang KL, Ngan HY, Liu JH, Wei LH, Mitrica I, Zhang P, Crescenzo R, Wang Q, Cox CJ, Harter P, du Bois A, Pazopanib Maintenance Therapy in East Asian Women With Advanced Epithelial Ovarian Cancer: Results From AGO-OVAR16 and an East Asian Study. Int J Gynecol Cancer 2015 Nov 19.

  • Lee YL, Fong SW, Chen AC, Li T, Yue C, Lee CL, Ng EH, Yeung WS, Lee KF.Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod. 2015 Sep 7. pii: dev223. [Epub ahead of print]

  • Lee CL, Guo Y, So KH, Vijayan M, Wong HHV, Yao Y, Lee CKF, Chiu CN and Yeung WSB. Soluble human leukocyte antigen G5 polarizes differentiation of macrophages towards a decidual macrophage-like phenotype. Human Reproduction 2015, 30: 2263-74.

  • Huang VW, Lee CL, Lee YL, Lam KK, Ko JK, Yeung WSB, Ho PC, Chiu PC. Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage. Molecular Human Reproduction 2015 Jun;21(6):516-26.

2014
  • Lee CL, Li K, Lam KW, Ng EHY, Koistinen H, Seppala M, Yeung WSB and Chiu CN. Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility. Molecular reproduction and development 2014, 81(6): 482-3.

  • Lee CL, Li K, Lam KK, Ng EH, Koistinen H, Seppälä M, Yeung WS, Chiu PC.Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility. Mol Reprod Dev. 2014 Jun;81(6):482-3. doi: 10.1002/mrd.22331. Epub 2014 May 9. [Medline]

2013
  • Guo YF, Lee CL, So KH, Gao J, Yeung WSB, Yao YQ, Lee KF. Soluble Human Leukocyte Antigen-G5 Activates Extracellular Signal-Regulated Protein Kinase Signaling and Stimulates Trophoblast Invasion. PLoS One 2013 Oct 1;8(10):e76023. [PubMed]

  • Huang VW, Zhao W, Lee CL, Lee CY, Lam KK, Ko JK, Yeung WS, Ho PC, Chiu PC. Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage. Fertil Steril. 2013 Apr;99(5):1444-1452. [PubMed]

  • Lee CL, Chiu PC, Hautala L, Salo T, Yeung WS, Stenman UH, Koistinen H. Human chorionic gonadotropin and its free β-subunit stimulate trophoblast invasion independent of LH/hCG receptor. Mol Cell Endocrinol. 2013 Aug 15;375(1-2):43-52. [PubMed]

  • Lee CL, Lam MPY, Lam KKW, Leung CON, Pang RTK, Chu IK, Wan THL, Chai J, Yeung WSB, Chiu PCN. The identification of CD147 (Basigin) as a mediator of trophoblast functions. Hum Reprod 2013 Sep. [ Epub ahead of print] [PubMed]

  • Pang RT, Leung CO, Lee CL, Lam KK, Ye TM, Chiu PC, Yeung WS. MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 2013 Jan 18;13:25. doi: 10.1186/1471-2407-13-25. [PubMed]

  • Wong BS, Lam KK, Lee CL, Wong VH, Lam MP, Chu IK, Yeung WS, Chiu PC. Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase plasminogen activator expression and s-nitrosylation. Biol Reprod. 2013 Feb 14;88(2):34. [PubMed]

2012
  • Chiu CN, Lam KK, Lee CL, Huang VW, Wong BS, Zhao W, Li K, Ho PC, Yeung WSB. Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men. Molecular Reproduction and Development 2012;79(2): 76. [PubMed]

  • Lam KK, Pang RT, Lee CL, Koistinen H, Seppala M, Ho PC, Yeung WS, Chiu PC. Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line. Placenta. 2012 Sep;33(9):750-2 [PubMed]

  • Lee CL, Lam EY, Lam KK, Koistinen H, Seppälä M, Ng EH, Yeung WS, Chiu PC. Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway. J Biol Chem. 2012 Oct 26;287(44):36999-7009. [PubMed]

  • So KH, Lee CL, Yeung WS, Lee KF. Glycodelin suppresses endometrial cell migration and invasion but stimulates spheroid attachment. Reprod Biomed Online. 2012;24(6):639-45. [PubMed]

2011
  • Lam KK, Chiu PC, Lee CL, Pang RT, Leung CO, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. J Biol Chem. 2011 Oct 28;286(43):37118-27. [PubMed]

  • Lee CL, Chiu PC, Lam KK, Siu SO, Chu IK, Koistinen R, Koistinen H, Seppälä M, Lee KF, Yeung WS. Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy. Hum Reprod. 2011 Mar;26(3):517-26. [Medline]

  • Lee CL, Chiu PC, Pang PC, Chu IK, Lee KF, Koistinen R, Koistinen H, Seppälä M, Morris HR, Tissot B, Panico M, Dell A, Yeung WS. Glycosylation failure extends to glycoproteins in gestational diabetes mellitus: evidence from reduced α2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A. Diabetes. 2011 Mar;60(3):909-17. [Medline]

  • Lee CL, Lam KK, Koistinen H, Seppala M, Kurpisz M, Fernandez N, Pang RT, Yeung WS, Chiu PC. Glycodelin-A as a paracrine regulator in early pregnancy. J Reprod Immunol. 2011 Jun;90(1):29-34.

  • Pang PC, Chiu PC, Lee CL, Chang LY, Panico M, Morris HR, Haslam SM, Khoo KH, Clark GF, Yeung WS, Dell A. Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida. Science. 2011 Sep 23;333(6050):1761-4. [PubMed]

2010
  • Chiu PC, Wong BS, Lee CL, Lam KK, Chung MK, Lee KF, Koistinen R, Koistinen H, Gupta SK, Seppälä M, Yeung WS. Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx. Hum Reprod 2010;25:2721-33.

  • Lee CL, Chiu CN, Lam KW, Chan RWS, Chu IK, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WSB. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Fertil Steril 2010;94:769-71. (Publication No. : 177299) 

  • Lee CL, Jiang P, Sit WH, Yang X, Wan JMF. Regulatory properties of polysaccharopeptide derived from Coriolus versicolor and its combined effect with ciclosporin on the homeostasis of human lymphocytes., Journal of Pharmacy and Pharmacology 2010;62:1028-36. (Publication No. : 180040) 

2008
  • Chiu PC, Wong BS, Lee CL, Pang RT, Lee KF, Sumitro SB, Gupta SK, Yeung WS. Native human zona pellucida glycoproteins: purification and binding properties. Hum Reprod. 2008 Jun;23(6):1385-93. [PubMed]

Research Grants
  • Ng EHY, Chiu PCN, Lee CL, Yeung WSB. Control of human decidual macrophage differentiation by glycodelin-A. University Grants Committee of Hong Kong (UGC) Research Grants Council (RGC) General research Fund. HK$1,297,160 (2012-2014)
  • Lee CL, Chiu PCN, Yeung WSB. Differential effects of glycodelin-A on human T-helper cell subsets: A mechanism producing an immune privilege environment for fetal development. The University of Hong Kong. Small Project Funding. HK$56,457 (2010-2012).
Awards and Honors
  • Strategic Research Areas and Themes (Development and Reproduction) Best Research Output Award - 2nd Prize. Lee CL, Chiu PCN, Pang PC, Chu IK, Lee KF, Koistinen R, Koistinen H, Seppälä M, Morris HR, Tissot B, Panico M, Dell A and Yeung WSB. Glycosylation failure extends to glycoproteins in gestational diabetes: Evidence from reduced alpha 2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A: Centre for Reproduction, Development and Growth, The University of Hong Kong