University Staff

Prof. P.C. HO hong kong university logo queen mary hosipital logo

Professor Pak Chung HO (何柏松教授)

Emeritus Chair Professor (Part-time)
MBBS ; MD (HK) ; FRCOG ; FHKCOG ; FHKAM (O&G)
  • location
    Rm 608, Professorial Block, Queen Mary Hospital
  • telephone
    (852)-2255-4518
  • facsimile
    (852)-2855-0947
  • pmykwok@hku.hk
  • HKU Scholars Hub
Research Interests
  • My clinical and research interests are in reproductive medicine. My main research areas are management of infertility, emergency contraception, medical abortion and clinical applications of mifepristone and misoprostol.

Publications

2017
  • Li HWR, Li YX, Li TT, Fan H, Ng EH, Yeung WS, Ho PC, Lee KF. Effect of ulipristal acetate and mifepristone at emergency contraception dose on the embryo-endometrial attachment using an in vitro human trophoblastic spheroid and endometrial cell co-culture model. Hum Reprod. 2017 Dec 1;32(12):2414-2422. doi: 10.1093/humrep/dex328.

2015
  • Yeung TWY, Chai J, Li RHW, Lee VCY, Ho PC and Ng EHY. Reply: Endometrial injury and reproductive outcomes: there's more to this story than meets the horse's blind eye. Human Reproduction 2015, 3: 749-750.

  • Li RHW, Lam KSL, Tam S, Lee VCY, Yeung TWY, Cheung PT, Yeung WSB, Ho PC and Ng EHY. Screening for dysglycaemia by oral glucose tolerance test should be recommended in all women with polycystic ovary syndrome. Human Reproduction 2015, 30(9): 2178-2183.

  • Lam KW, Li RHW, Ng EHY, Ho PC and Yeung WSB., Semen analysis - what a clinician should know. Journal of Paediatrics, Obstetrics and Gynaecology Singapore 2015, Jan: 37-44.

  • Kim JW, Mahner S, Wu LY, Shoji T, Kim BG, Zhu JQ, Takano T, Park SY, Kong BH, Wu Q, Wang KL, Ngan HY, Liu JH, Wei LH, Mitrica I, Zhang P, Crescenzo R, Wang Q, Cox CJ, Harter P, du Bois A, Pazopanib Maintenance Therapy in East Asian Women With Advanced Epithelial Ovarian Cancer: Results From AGO-OVAR16 and an East Asian Study. Int J Gynecol Cancer 2015 Nov 19.

  • Chow JFC, Yeung WSB, Lee VCY, Lau EYL, Ho PC and Ng EHY Experience of more than 100 preimplantation genetic diagnosis cycles for monogenetic diseases using whole genome amplification and linkage analysis in a single centre. Hong Kong Medical Journal 2015, 21(4): 299-303.

  • Chan CHY, Chan THY, Chan CLW, Ng EHY and Ho PC. Diagnostic ambiguity and psychosocial distress among Chinese women with idiopathic and non-idiopathic infertility. Illness, Crisis & Loss 2015, 23(1): 45-48.

  • Chai J, Lee VCY, Yeung TW., Li RHW, Ho PC and Ng EHY Live birth and cumulative live birth rates in expected poor ovarian responders defined by the Bologna criteria following IVF/ICSI treatment. PLoS One 2015 Mar 6;10(3):e0119149.

  • Lee VC, Chow JF, Lau EY, Yeung WS, Ho PC, Ng EH. Comparison between fluorescent in-situ hybridisation and array comparative genomic hybridisation in preimplantation genetic diagnosis in translocation carriers. Hong Kong Med J. 2015 Feb;21(1):16-22. doi: 10.12809/hkmj144222. Epub 2014 Oct 24. [PubMed]

  • Huang VW, Lee CL, Lee YL, Lam KK, Ko JK, Yeung WSB, Ho PC, Chiu PC. Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage. Molecular Human Reproduction 2015 Jun;21(6):516-26.

2014
  • Chai J, Yeung WYT, Lee VCY, Li RHW, Ho PC, Ng HYE. Live birth rates following in vitro fertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism.  Clin Endocrinol (Oxf) 2014; 82(1): 122-127.

  • Yeung TWY, Chai J, Li RHW, Lee VCY, Ho PC, Ng EHY. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod 2014; 29(11): 2474-2481.

  • Yeung TWY, Chai J, Li RHW, Lee VCY, Ho PC and Ng EHY. A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertility and Sterility 2014, 102: 108-115.e1.

  • Wang Q, Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. (2014) Preimplantation genetic diagnosis using combined strategies on a breast cancer patient with a novel genomic deletion in BRCA2. Journal of Assisted Reproduction & Genetics 2014;31(12):1719-26

  • Li RHW, Lo STS and Ho PC. Emergency contraception. Best Practice & Research Clinical Obstetrics & Gynaecology 2014, 28: 835-844.

  • Li RHW, Liao S., Yeung WSB, Ng EHY, O WS and Ho PC. Ulipristal acetate resembles mifepristone in modulating human Fallopian tube function. Human Reproduction 2014 29: 2156-2162.

  • Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC, Ng EHY. Ovarian response and cumulative live birth rate of women undergoing in-vitro fertilisation who had discordant anti-mullerian hormone and antral follicle count measurements: a retrospective study.  PLoS One 014;9(10):e108493.

  • Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Role of baseline antral follicle count and anti-Mullerian hormone in the index stimulation cycle of IVF treatment in predicting outcome of subsequent frozen-thawed embryo transfers. Gynecological Endocrinology 2014 30: 490-493.

  • Li RHW, Lee VCY, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment. Journal of Assisted Reproduction and Genetics 2014, 31: 205-211.

  • Li RHW, Lee VCY, Ho PC and Ng EHY. Ovarian sensitivity index is a better measure of ovarian responsiveness to gonadotrophin stimulation than the number of oocytes during in-vitro fertilization treatment. Journal of Assisted Reproduction and Genetics 2014, 31: 199-203.

  • Lee VCY, Chow JFC, Lau EYL, Yeung WSB, Ho PC, Ng EHY. Live birth following double-factor pre-implantation genetic diagnosis for both reciprocal translocation and alpha-thalassaemia. Hong Kong Med J 2014 Jun;20(3):251-4.

  • Lee VCY, Li RHW, Chai J, Yeung TWY, Yeung WSB, Ho PC and Ng EHY. Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen–thawed embryo transfer in natural cycles. Fertility and Sterility 2014, 101: 1288-1293.

  • Ko JKY, Huang VW, Li RHW, Yeung WSB, Ho PC and Chiu CN. An in vitro study of the effect of mifepristone and ulipristal acetate on human sperm functions. Andrology 2014;2(6):868-874.

  • Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage. Reprod Biol Endocrinol. 2014 Nov 24;12:105.

  • Chai J, Yeung TWY, Lee VCY, Li RHW, Lau EYL, Yeung WSB, Ho PC and Ng EHY. Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience. Hong Kong Medical Journal 2014, 20(2):102-106.

  • Chow JF, Yeung WS, Lau EY, Lee VC, Ng EH, Ho PC. Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage. Reprod Biol Endocrinol. 2014 Nov 24;12:105. doi: 10.1186/1477-7827-12-105. [PubMed]

  • Li HW, Liao SB, Yeung WS, Ng EH, O WS, Ho PC. Ulipristal acetate resembles mifepristone in modulating human Fallopian tube function.Hum Reprod. 2014 Aug 19. pii: deu210. [Epub ahead of print]

  • Chai J, Yeung WY, Lee CY, Li HW, Ho PC, Ng HY. Live birth rates following in vitro fertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism. Clin Endocrinol (Oxf). 2014 Jan;80(1):122-7. [PubMed]

2013
  • Chai J, Wong CY, Ho PC. A randomized clinical trial comparing the short-term side effects of sublingual and buccal routes of misoprostol administration for medical abortions up to 63 days' gestation. Contraception. 2013 Apr;87(4):480-5. [PubMed]

  • Lee VC, Gao J, Lee KF, Ng EH, Yeung WS, Ho PC. The effect of letrozole with misoprostol for medical termination of pregnancy on the expression of steroid receptors in the placenta. Hum Reprod 2013 Nov;28(11):2912-9.[PubMed]

  • Huang VW, Zhao W, Lee CL, Lee CY, Lam KK, Ko JK, Yeung WS, Ho PC, Chiu PC. Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage. Fertil Steril. 2013 Apr;99(5):1444-1452. [PubMed]

  • Lee VC, Li RH, Ng EH, Yeung WS, Ho PC. Luteal phase support does not improve the clinical pregnancy rate of natural cycle frozen-thawed embryo transfer: a retrospective analysis. Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(1):50-3. [PubMed]

  • Li HW, Lee VC, Lau EY, Yeung WS, Ho PC, Ng EH. Role of baseline antral follicle count and anti-Mullerian hormone in prediction of cumulative live birth in the first in vitro fertilisation cycle: a retrospective cohort analysis. PLoS One. 2013 Apr 23;8(4):e61095. [PubMed]

  • Tiwari A, Fong DY, Chan CH, Ho PC. Factors mediating the relationship between intimate partner violence and chronic pain in Chinese women. J Interpers Violence. 2013 Mar;28(5):1067-87. [PubMed]

  • Yeung TW, Li RH, Lee VC, Ho PC, Ng EH. A randomized double-blinded placebo-controlled trial on the effect of dehydroepiandrosterone for 16 weeks on ovarian response markers in women with primary ovarian insufficiency. J Clin Endocrinol Metab. 2013 Jan;98(1):380-8. [PubMed]

2012
  • Chan CHY, Chan CLW, Ng EHY, Ho PC, Lee GL, Hui CWH. Incorporating spirituality in psychosocial group intervention for women undergoing in vitro fertilization: A prospective randomized controlled study. Psychology and Psychotherapy. 2012, 85(4): 356-373. 

  • Chan EKL, Brownridge DA, Fong DYT, Tiwari AFY, Leung WC, Ho PC. Violence against pregnant women can increase the risk of child abuse: A longitudinal study.Child Abuse & Neglect. 2012, 36(4): 275-284. 

  • Chen AC, Lee YL, Hou DY, Fong SW, Peng Q, Pang RT, Chiu PC, Ho PC, Lee KF, Yeung WS. Study of transforming growth factor alpha for the maintenance of human embryonic stem cells. Cell Tissue Res. 2012 Nov;350(2):289-303. [Medline]

  • Chiu CN, Lam KK, Lee CL, Huang VW, Wong BS, Zhao W, Li K, Ho PC, Yeung WSB. Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men. Molecular Reproduction and Development 2012;79(2): 76. [PubMed]

  • Kodithuwakku SP, Pang RT, Ng EH, Cheung AN, Horne AW, Ho PC, Yeung WS, Lee KF. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92(2):256-64. [Medline]

  • Lam KK, Pang RT, Lee CL, Koistinen H, Seppala M, Ho PC, Yeung WS, Chiu PC. Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line. Placenta. 2012 Sep;33(9):750-2 [PubMed]

  • Lee VC, Yeung TW, Tang OS, Ng EH, Yeung WS, Ho PC. Effect of letrozole on uterine artery Doppler flow indices prior to first-trimester termination of pregnancy: a randomized controlled trial. Ultrasound Obstet Gynecol. 2012 Oct;40(4):392-7. [PubMed]

  • Lee VCY, Ng EHY, Ho PC. (2012) Male infertility. Journal of Paediatrics, Obstetrics and Gynaecology, Sept-Oct, 213-220.

  • Li HW, Ng EH, Wong BP, Anderson RA, Ho PC, Yeung WS. Correlation between three assay systems for anti-Müllerian hormone (AMH) determination. J Assist Reprod Genet. 2012 Dec;29(12):1443-6.

  • Ng EHY and Ho PC. (2012) Preface Best Practice & Research Clinical Obstetrics and Gynaecology 26, 727.

  • Yeung TWY, Lee VCY, Ng EHY, Ho PC. A pilot study on the use of a 7-day course of letrozole followed by misoprostol for the termination of early pregnancy up to 63 days. Contraception, 2012 Dec;86(6):763-9. [PubMed]

2011
  • Yeung TWY, Ho PC. Dehydroepiandrosterone (DHEA) – The Answer to Diminished Ovarian Reserve. Journal Of Paediatrics, Obstetrics and Gynaecology. Sept-Oct 2011: 213-220.

  • Chai J, Hon E, Li CF, Pun TC, Yeung WSB, Ho PC. A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy. Eur J Obstet Gynecol Reprod Biol. 2011 Sep;158(1):72-5. [PubMed]

  • Chai J, Lee KF, Ng EH, Yeung WS, Ho PC. Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles. Fertil Steril. 2011 Sep;96(3):764-8. [Medline]

  • Chan KL, Brownridge DA, Tiwari A, Fong DY, Leung WC, Ho PC. Associating pregnancy with partner violence against Chinese women. J Interpers Violence. 2011 May;26(7):1478-500.

  • Ho PC. Clinical Applications of Letrozole in Reproductive Medicine. 2011;1:25. 

  • Kodithuwakku SP, Ng PY, Liu Y, Ng EHY, Yeung WSB, Ho PC, Lee KF. Hormonal regulation of endometrial olfactomedin expression and its suppressive effect on spheroid attachment onto endometrial epithelial cells. Hum Reprod 2011;26:167-175. [Medline]

  • Lam KK, Chiu PC, Lee CL, Pang RT, Leung CO, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. J Biol Chem. 2011 Oct 28;286(43):37118-27. [PubMed]

  • Lee VC, Chan CC, Ng EH, Yeung WS, Ho PC. Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial. Reprod Biomed Online. 2011 Sep;23(3):380-8.

  • Lee VC, Ng EH, Yeung WS, Ho PC. Misoprostol with or without letrozole pretreatment for termination of pregnancy: a randomized controlled trial. Obstet Gynecol. 2011 Feb;117(2 Pt 1):317-23 [PubMed]

  • Lee VC, Tang OS, Ng EH, Yeung WS, Ho PC. A pilot study on the use of letrozole with either misoprostol or mifepristone for termination of pregnancy up to 63 days. Contraception. 2011 Jan;83(1):62-7.

  • Lee VC, Tang OS, Ng EH, Yeung WS, Ho PC. A prospective double-blinded, randomized, placebo-controlled trial on the use of letrozole pretreatment with misoprostol for second-trimester medical abortion. Contraception. 2011 Dec;84(6):628-33.

  • Lee VC, Yung SS, Li RH, Watzer B, Schweer H, Ng EH, Ho PC. A randomized comparison of pharmacokinetics of a single vaginal dose of dry misoprostol or misoprostol moistened with normal saline or with acetic acid. Hum Reprod. 2011 Nov;26(11):2981-7. [PubMed]

  • Li HWR, Yeung WSB, Lau EY, Ho PC, Ng EHY. Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination. Fertil Steril. 2010;94:2177-81. [PubMed]

  • Li RHW, Anderson RA, Yeung WS, Ho PC, Ng EH. Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea. Fertil Steril. 2011 Sep;96(3):774-9. [PubMed]

  • Li RHW, Gebbie AE, Wong RWS, Ng EHY, Glasier AF, Ho PC. The use of sex hormones in women with rheumatological diseases. Hong Kong Med J 2011;17(6):487-491.

  • Li RHW, Lo SST, Ng EHY, Ho PC. An update on emergency contraception. J Paediat, Obst & Gyna 2011;36:81-88.

  • Li RHW, Ng EHY, Ho PC. Handbook on Managing Infertility (Meeting the Challenges in Low-Resource Settings) - Asia and Oceania Federation of Obstetrics and Gynaecology. Polycystic Ovary Syndrome and Infertility 2011;11:105-111.

  • Li RHW, Wong GCY, Yeung WSB, Ho PC, Ng EHY. Serum anti-mullerian hormone level is not altered in women using hormonal contraceptives. Contraception 2011;83:582-585.

2010
  • Chan CH, Tiwari AFY, Fong DYT, Ho PC. Post-traumatic stress disorder among Chinese women survivors of intimate partner violence: A review of the literature, International Journal of Nursing Studies. 2010;47:918-925.

  • Chan EKL, Brownridge DA, Tiwari AFY, Fong DYT, Leung WC, Ho PC. Associating pregnancy with partner violence against Chinese women, Journal of Interpersonal Violence. 2010;26(7):1478-1500.

  • Chiu CN, Liao S, Lam KW, Tang F, Ho JCM, Ho PC, O WS, Yao QY, Yeung WSB. Adrenomedullin regulates sperm motility and oviductal ciliary beat via cyclic adenosine 5'-monophosphate/protein kinase A and nitric oxide, Endocrinology. 2010;151:3336-3347. [PubMed]

  • Lee KF, Lee YL, Chan RWS, Cheong AWY, Ng EHY, Ho PC, Yeung WSB. Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue, Fertility and Sterility. 2010;93:1052-1060. (Publication No. : 175168)

  • Lee VCY, Ng EHY, Ho PC. Issues in second trimester induced abortion (medical/surgical methods). Best Pract Res Clin Obstet Gynaecol. 2010;24:517-27.

  • Lee VCY, Ng EHY, Yeung WSB, Ho PC. Impact of positive hepatitis B surface antigen on the outcome of IVF treatment. Reprod Biomed Online 2010;21:712-7.

  • Li HWR, Hui PW, Tang MHY, Lau ET, Yeung WSB, Ho PC, Ng EHY. Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies. Prenat Diagn. 2010;30:320-4.

  • Li HWR, Liao S, Chiu PCN, Tam WW, Ho JCM, Ng EHY, Ho PC, Yeung WSB, Tang F, O WS, Expression of adrenomedullin in human oviduct, its regulaton by the hormonal cycle and contact with spermatozoa, and its effect on ciliary beat frequency of the oviductal epithelium, Journal of Clinical Endocrinology and Metabolism. 2010;95:E18-E25. (Publication No. : 182871) 

  • Li HWR, Ng EHY, Ho PC. Clinical applications of misoprostol in gynaecology.  J Paed Obstet Gynaecol 2010;36: 81-88.

  • Liu Y, Kodithuwakku SP, Ng PY, Chai J, Ng EH, Yeung WS, Ho PC, Lee KF. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. Hum Reprod 2010;25:479-90. [PubMed]

  • Ng EHY, Ho PC. Ultrasound assessment of endometrial receptivity in in vitro fertilization treatment. DonaldSchool Journal of Ultrasound in Obstetrics and Gynecology 2010;4:179-188.

  • So WS, Ng EHY, YY Wong, EYL Lau, WSB Yeung, Ho PC. Acupuncture for frozen-thawed embryo transfer cycles: a double-blind randomized controlled trial. Reproductive BioMedicine Online 2010;20,814-821.

  • Yeung WS, Li RH, Cheung TM, Ng EH, Lau EY, Ho PC. Frozen-thawed embryo transfer cycles. Hong Kong Med J. 2009;15:420-6.

2009
  • Lam KK, Chiu PC, Chung MK, Lee CL, Lee KF, Koistinen R, Koistinen H, Seppala M, Ho PC, Yeung WS. Glycodelin-A as a modulator of trophoblast invasion. Hum Reprod. 2009 Sep;24(9):2093-103. [PubMed]

  • Chai J, Tang OS, Hong QQ, Chen QF, Cheng LN, Ng E, Ho PC. A randomized trial to compare two dosing intervals of misoprostol following mifepristone administration in second trimester medical abortion. Hum Reprod. 2009 Feb;24(2):320-4. [PubMed]

2008
  • Lee YL, Liu Y, Ng PY, Lee KF, Au CL, Ng EH, Ho PC, Yeung WS. Aberrant expression of angiopoietins-1 and -2 and vascular endothelial growth factor-A in peri-implantation endometrium after gonadotrophin stimulation. Hum Reprod. 2008 Apr;23(4):894-903. [PubMed]

  • Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020. Epub 2008 Jan 14. [PubMed]

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Research Grants
  • Combined use of letrozole and misoprostol for medical termination of pregnancy. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2008-2009 (Principal Investigator) HK$ 747,000 (2008-2011)
  • Adrenomedullin and sperm functions. University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) General Research Fund (GRF) 2006-2007 (Principal Investigator) HK$ 654,500 (2006-2009)